Bio Saga Headlines

Bio Saga

Tuesday, March 17, 2009

Gel for Controlled Drug Delivery

Massachusetts Institute of Technology (MIT) researchers have demonstrated that a gel composed of small, woven protein fragments can successfully carry and release proteins of different sizes, potentially enabling the delivery of drugs such as insulin and trastuzumab (Herceptin).

Researchers can control the rate of release by changing the density of the gel, allowing for continuous drug delivery over a specific period of time. The team is led by Shuguang Zhang, associate director of MIT's Center for Biomedical Engineering.

The gel, known as a "nanofiber hydrogel scaffold," enables a gradual release of the proteins from the gel over hours, days or even months. The gel itself is eventually broken down into harmless amino acids - the building blocks of proteins. Peptide hydrogels are ideally suited for drug delivery as they are pure, easy to design and use, non-toxic, non-immunogenic, bio-absorbable, and can be locally applied to a particular tissue.

Composed of self-assembling amino acid chains (peptides), the gel is about 99 percent water by volume. Depending on the size and density of the mesh, it can carry protein molecules between 14,000 and 150,000 daltons (a unit of molecular weight). Trastuzumab, an antibody protein often used to treat breast and ovarian cancer under the brand name Herceptin, is about 50,000 daltons. Researchers also showed that proteins carried by the gel emerge unscathed after delivery, with no adverse affect on their function.

Potential applications include delivery of insulin, monoclonal antibodies such as Herceptin, hormones, growth factors and cancer drugs, as well as eye medications.


Be part of XTractor community.

  • XTractor the first of its kind - Literature alert service, provides manually curated & annotated sentences for the Keywords of your choice
  • XTractor maps, extracted entities (genes, processes, drugs, diseases etc) to multiple ontologies
  • Enables customized report generation. With XTractor the sentences are categorized into biologically significant relationships
  • The categorized sentences could then be tagged and shared across multiple users
  • Provides users with the ability to create his own database for a set of Key terms
  • Users could change the Keywords of preference from time to time, with changing research needs
  • XTractor thus proves to be a platform for getting real-time highly accurate data along with the ability to Share and collaborate


Sign up it's free, and takes less than a minute. Just click here:www.xtractor.in.











No comments:

Life Science and Informatics

What is this?
is this a new industry?
or a old wine in a new bottle?

Well Life Sciences and Informatics can be anything form computational biology, all omes and omics, core bioinformatics to curation and literature mining, database creation, in the area of biology, chemistry , bio-chem space.

There are number of companies in India and bangalore is the forefront as a major bio-cluster with 20 to 30 companies in this sphere.

now how good are these companies doing?
how good are they in terms of the international markets and how profitable is their business?
what do they do?
their clients?

These are some interesting things that could be discussed in this blog page...

Tag It