Bio Saga Blog - A Chronicle of Life Sciences & Informatics

Recently I had shared a piece of news on the same topic:-  https://www.linkedin.com/feed/update/urn:li:activity:6590633791084163072/ # lims hashtag # laboratories hashtag # datamanagement hashtag # flexible Data Management Challenges In Next Generation Sequencing Since the beginning of the Human Genome Project, data management has been perceived as a key challenge for current molecular biology research. Before the finish of the nineties, advances had been set up that adequately bolstered most continuous activities, ordinarily based upon relational database management frameworks. Ongoing years have seen a sensational increment in the amount of information created by running projects that extends in this area. While it took over ten years, roughly three billion USD, and in excess of 200 gatherings worldwide to collect the main human genome, the present sequencing machines create a similar amount of crude information in seven days, at an expense of around 2000 USD...

"Prime editing" is more precise and more efficient than CRISPR and could herald a new era of genetic manipulation. The ability to edit the genes of human beings by changing the code of life -- DNA -- has dramatically improved over the last decade. Current tools, like  CRISPR-Cas9 and  base editors , are extremely powerful but have traditionally suffered from a lack of precision, high error rate and limited scope, hampering their ability to treat human genetic disease. A breakthrough gene-editing tool, developed by a team of researchers at Harvard University and unveiled Monday, has the ability to make extremely precise DNA edits, ushering in a new era of genetic manipulation. "In many respects this first report is the beginning rather than the end of a longstanding aspiration ... to be able to make any DNA change in any position of a living cell or organism including, potentially, human patients with genetic diseases," says David Liu, a chemist at Harvard'...

https://youtu.be/TdBAHexVYzc