Bio Saga Blog - A Chronicle of Life Sciences & Informatics

              Know About Our Workshop On Bioinformatics and Protein Structure Prediction 10th to 12th May 2019 | Pune, India | 09:30 AM - 05:00 PM Our 3 day comprehensive workshop on Bioinformatics and Protein Structure Prediction aims at providing systematic Hands-on-Training on Protein visualization, mutation & other manipulations.Understand concept of in-silico protein modelling using servers & software’s.Understanding concept of protein motif and domains.Understanding concept of protein structure prediction by Modeller COMPREHENSIVE & SEQUENTIAL SESSIONS ON: ▪ Introduction to Biological databases ▪ Multiple Sequence Alignment – CLUSTALW ▪ Introduction to Proteins & Protein Databases-UNIPROT ▪ Study of proteins and their structures ▪ Protein Secondary Structure Prediction tools ▪ Protein Tertiary Structure Prediction using Servers & Modeller ▪ Protein Structure Validation ...

The malaria parasite has waged a successful guerrilla war against the human immune system for eons, but a study in this week's Journal of Biological Chemistry has exposed one of the tricks malaria uses to hide from the immune proteins, which may aid in future drug development. Malaria parasites (plasmodia) are transmitted to people via infected mosquitoes. Once inside their human hosts the parasites first set up shop in liver cells, then move into red blood cells (RBCs) to replicate and wait for the next mosquito to help continue the cycle. After plasmodia infect a blood cell, they send out clusters of sticky proteins to the cell surface, enabling them to attach to blood vessels and escape destruction by the host's spleen while they replicate. This tactic can be especially problematic during pregnancy as malaria-infected RBCs congregate in the vessel-rich placenta (the source of food and oxygen for the growing fetus), creating health problems such as anemia, low birth-weight, f...

Bioinformatics firm Biosof said today that it is working with IBM to provide a server platform for its PredictProtein product for analyzing protein structure and function. The collaboration will enable Biosof’s customers to use ProteinPredict through a virtual private network or on-site installation while running IBM’s high-performance computing hardware, New York-based Biosof said in a statement. “Working with IBM provides our customers the unique opportunity to combine a secure infrastructure and cutting-edge hardware needed to run our highly resource-intensive algorithms,” said Burkhardt Rost, a manager of Biosof. Be a part of the XTractor community. XTractor is the first of its kind - Literature alert service , that provides manually curated and annotated sentences for the Keywords of user preference. XTractor maps the extracted entities (genes, processes, drugs, diseases etc) to multiple ontologies and enables customized report generation. With XTractor the sentences are ...

Here is a abstract that i had submitted at the Plant & Animal Genomes XI Conference January 11-15, 2003 Town & Country Convention Center San Diego, CA. I do not know how relevant is the issue to this day. If any one is interested or if any one is working in these lines, do let me know also pour in your suggestions and comments if any. Fiber quality in cotton is one very vital trait demanding international focus in both scientific and commercial arena. Phytohormones play a major role in all cellular processes in plant development. We have focused our study on the influence of phytohormones in improving the staple length of cotton fiber. There are several pathways, which influence staple length in cotton, among which we have concentrated on the expression pattern of Lipid Transfer Protein3. A cotton fiber protein gene Ltp3, Lipid transfer protein3 (coding for a LTP3 protein), is specifically expressed in fibers at high levels, during the elongation stage. Its levels reach a maxim...

Dr. Ronald Collman talks about exciting new discoveries on HIV, the virus that has taken 25 million lives. Dr. Ronald Collman , professor of medicine in microbiology, virus/cell/molecular core director, Penn Center for AIDS Research, University of Pennsylvania.He describes the molecular structure, pathology, and with great insight, the incredible discoveries that might just help us conquer HIV. Listen to the Original audio source

Here is a abstract that i had submitted at the 3D sig:Structral Bioinformatics at the 1st Structural Bioinformatics Meeting at ISMB 29-30 July 2004, Glasgow, Scotland, UK. I do not know how relevant is the issue to this day. I am interested in working further in this area and i am interested in collaborating. Do let me know your comments also pour your suggestions on how to further this study. In silico methods can be used to design protein, based on stability and functionality using computational methods rather than laboratory procedures (Comet et al., 2000). The changes taking place due to the transfer of motif region from human Catechol-O-methyltansferase to rat Catechol-O-methyltransferase can be studied effectively using computational methods. This will provide insight for further development of the study about the function of neurotransmitter region of catechol-O-methyltransferase and its involvement in the Parkinson’s disease. Catechol-O-methyltransferase (COMT) catalyzes the t...

Scientists at Edinburgh University have been studying complex mathematical models on a highly powerful computing system to look at the case of the Amazon Molly. Researchers calculated the time to extinction for the fish based on modelling genetic changes over many thousands of generations. They are now able to say conclusively, for the first time, the fish ought to have become extinct within the past 70,000 years, based on the current simple models. Evolution @ home is the first global computing system for evolution ary biology. It allows everybody with an Internet PC to contribute to evolution ary-research by running simulations of evolution . The research is published in the journal BMC Evolutionary Biology. and the News is on BBC too