Bio Saga Blog - A Chronicle of Life Sciences & Informatics

26th- 27th Feb 2011 Workshop groups will study problems with hands-on examples using computational chemistry methods and discuss issues highlighted by examples and Case Studies presented by instructors. A Case Study set with a focus on chemical database creation and filtering drug like compounds will be used to link all workshop activities throughout the workshop. Hands on training on commercial softwares of Drug discovery Application of Chemoinformatics in drug discovery Interaction and guidance from eminent scientist from NCL Training from industry experts from Chemoinformatics domain. Analyzing chemical fingerprint Generating Knowledge from structure and different chemical databases Using various chemical structure drawing and visualization tools Digitizing your chemical Data. Storing molecules in wide array of format Awards for top 3 groups For any queries contact: RASA Life Science Informatics 301, 3rd Floor, Dhanashree Apartment, Opposite Chittaranjan Vatika, ...

Brookhaven Lab researchers Subramanyam Swaminathan, Desigan Kumaran and Richa Rawat. "We have found a highly efficient inhibitor of botulinum neurotoxin type A - the most potent of seven neurotoxins produced by the bacterium Clostridium botulinum. This finding can lead to a very effective drug to stop the devastating effects of the toxin," said Dr. Subramanyam Swaminathan, Botulinum neurotoxin -- responsible for the deadly food poisoning disease botulism and for the beneficial effects of smoothing out facial wrinkles - can also be used as a dreaded biological weapon. When ingested or inhaled, less than a billionth of an ounce can cause muscle paralysis and eventual death. Although experimental vaccines administered prior to exposure can inhibit the destructive action of this neurotoxin - the most deadly protein known to humans -- no effective pharmacological treatment exists. Scientists have now taken the first step toward designing an effective antidote to the most potent ...

Indian Drug Database An attempt is made to collect/design the Indian approved drugs and the experimentally determined and computed three-dimensional (3D)-structures and their functional annotations are deposited... Do you want to know more?

Research archive doubles in size since 2004 NEW BRUNSWICK, N.J. The Protein Data Bank ( PDB ) based at Rutgers, The State University of New Jersey, and the University of California-San Diego (UCSD) this month reached a significant milestone in its 37-year history. The 50,000th molecule structure was released into its archive, joining other structures vital to pharmacology , bioinformatics and education. With its origins in a handwritten petition circulated at a scientific meeting, the PDB is the single worldwide repository for the three-dimensional structures of large molecules and nucleic acids। This freely available online library allows biological researchers and students to study, store and share molecular information on a global scale. Officially founded in 1971 with seven structures at Brookhaven National Laboratory, the archive is managed by a consortium called the worldwide Protein Data Bank ( wwPDB ). Today, the PDB archive receives approximately 25 new experimentally determi...

" Work created before the existence of copyright and patent laws also form part of the public domain . The Bible and the inventions of Archimedes are in the public domain. However, copyright may exist in translations or new formulations of this work. " [ Wikipedia ] As posted by Tony is the Chemical Abstract Service (CAS) discouraging using their CAS services for assigning correct CAS numbers to structures for any third party database. Wikipedia is a source of structures, which is public domain due to its GNU FDL . Still, this does not imply that any translation of structures, e.g. CAS numbers, are in the public domain, too. Honestly, this raises a serious problem for curating CAS numbers on Wikipedia and this raises indeed the question, if they should not be dropped from Wikipedia, and any other information source, at all? Is it not better having no information, than having wrong information? A CAS number is for me only one certain translation of a chemical structure....