Roughly 80 percent of known protein coding genes in Saccharomyces cerevisiae are nonessential

Using chemical genomics, researchers from Stanford University and the University of Toronto demonstrated that the majority of yeast nonessential single deletions exhibit growth defects when exposed to certain chemical or environmental stress. They also identified new candidate multi-drug resistance genes and demonstrated how clustering genes based on their co-fitness can provide clues about their function. The work appeared online today in Science.

“The emergent field of chemical genomics promises that, by understanding the relations between small molecules and genes on a systems level, we might understand genomic responses to small molecule perturbants,”

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