Bio Saga Headlines

Bio Saga

Wednesday, May 7, 2008

Biomarkers to Open the Door to Personalized Medicine and Represents a Seismic Shift for the Pharma Industry

“For example, the presence of a specific protein in the blood or in any body fluid might indicate a specific infection. Once an association between a biomarker and a disease is clearly established, the one can be used to signal the other, and to a high degree of certainty. As well, changes in the prevalence of a biomarker in the organism can immediately and reliably signpost a patient’s response to treatment”

Some pharmaceutical companies are already advancing their research and harnessing the power of biomarkers, which can:
  • Be used to detect the predisposition for disease in a population, screen for its presence, confirm its diagnosis, assess its severity, predict its response to available therapies and measure its clinical course
  • Be used as targets to discover new drugs
  • Be a decisive factor in determining whether or not to continue research on an entity
  • Show early in the development phase whether an entity could lead to side effects that should terminate further research
  • Help to make clinical trials more efficient
  • Reduce treatment overheads by optimizing dosages and measuring a patient’s response more quickly and accurately
Molecular Connections Private Ltd. Bangalore India has announced the launch of its new Knowledgebase of Clinically Significant Proteins - CliPro.
  • Knowledgebase, is a result of manually mining thousands of papers, on proteins present in various human body fluids , with their known concentration values and biomarker information as available in literature
  • Platform to analyze protein biomarker- disease associations
  • Catalogue of clinically significant proteins in biofluids such as plasma, cerum, CSF, synovial fluid, saliva, urine, peritonial fluid, bal fluid, amniotic fluid, tears
  • includes >1000 clinically significant proteins – with ~2000 different disease/pathological correlations
  • Biomarkers with disease associations are broadly either diagnostic, prognostic, predictive or efficacy markers
Also read A price tag of around US$1 billion to map human proteome

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Life Science and Informatics

What is this?
is this a new industry?
or a old wine in a new bottle?

Well Life Sciences and Informatics can be anything form computational biology, all omes and omics, core bioinformatics to curation and literature mining, database creation, in the area of biology, chemistry , bio-chem space.

There are number of companies in India and bangalore is the forefront as a major bio-cluster with 20 to 30 companies in this sphere.

now how good are these companies doing?
how good are they in terms of the international markets and how profitable is their business?
what do they do?
their clients?

These are some interesting things that could be discussed in this blog page...

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