Researchers create molecule that nudges nerve stem cells to mature

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The last time i blogged on stem cells it was rather about a challenge in Fresh hurdle for stem cell hunt, but this time its more on a positive note and fairly quite an interesting and welcome news... a SERENDIPITY!

Inspired by a chance discovery during another experiment, researchers at UT Southwestern Medical Center have created a small molecule that stimulates nerve stem cells to begin maturing into nerve cells in culture.

"This provides a critical starting point for neuro-regenerative medicine and brain cancer chemotherapy," said Dr. Jenny Hsieh, assistant professor of molecular biology and senior author of the paper, Small-molecule activation of neuronal cell fate, Jay W Schneider, Zhengliang Gao, Shijie Li, Midhat Farooqi, Tie-Shan Tang, Ilya Bezprozvanny, Doug E Frantz, Jenny Hsieh
SUMMARY: We probed an epigenetic regulatory path from small molecule to neuronal gene activation. Isoxazole small molecules triggered robust neuronal differentiation in adult neural stem.
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